Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration

Intra-articular Delivery of Kartogenin Conjugated Chitosan Nano/microparticles for Cartilage Repair

Development of kartogenin-conjugated chitosan-hyaluronic acid hydrogel for nucleus pulposus regeneration.

Injectable constructs for in vivo gelation have many advantages in the regeneration of degenerated nucleus pulposus. In this study, an injectable hydrogel consisting of chitosan (CS) and hyaluronic acid (HA) crosslinked with glycerol phosphate (GP) at different proportions (CS : GP : HA, 6 : 3 : 1, 5 : 3 : 2, 4 : 3 : 3, 3 : 3 : 4, 2 : 3 : 5, 1 : 3 : 6, V : V : V) was developed and employed as a...

Advanced cell therapies for articular cartilage regeneration.

Advanced cell-based therapies are promising approaches for stimulating full regeneration of cartilage lesions. In addition to a few commercially available medicinal products, several clinical and preclinical studies are ongoing worldwide. In preclinical settings, high-quality cartilage tissue has been produced using combination strategies involving stem or progenitor cells, biomaterials, and bi...

The Effect of Intra-articular Corticosteroids on Articular Cartilage

BACKGROUND Intra-articular (IA) corticosteroid therapy has been used for the treatment of inflammation and pain in the knee since the 1950s. PURPOSE To review the current literature on the effects of IA corticosteroids on articular cartilage. STUDY DESIGN Systematic review. METHODS A MEDLINE and SCOPUS database search was performed, and studies were selected for basic science and clinical...

Electrical stimulation of articular cartilage regeneration.

The fact that bone is stress electrogenic is well substantiated. Becker and colleagues have proposed that this property is the biological signal that regulates Wolff's law, whereas others have observed osteogenic responses to electrical voltages and currents. Becker and Murray detected electrical control signal characteristics in fractured long bones. The above findings and the work of Smith, w...